Sodium HyaluronateHyaluronic Acid
Always by your side
Customer friendly Sodium Hyaluronate
We can provide the best solution for your specific application.
We have Sodium hyaluronate with a wide range of molecular weights and are able to develop tailor made derivatives.
Timely expert technical support
We promote development for your product with our technical support by R&D experts and regulatory support.
Japanese manufacturing
Long history
Kewpie has been in the food industry with a history of more than 100 years.
Kewpie has continued to be a pioneer manufacturer of Sodium hyaluronate since 1983.
In 1983 we developed our first Sodium hyaluronate from Chicken Comb.
Since our company also manufactures vinegar, we utilized the fermentation technology of vinegar used for our famous mayonnaise.
By using this fermentation technology we have switched our manufacturing process to biofermentation of Lactobacillus.
Since 2016 we have developed and manufactured medical devices using our Sodium hyaluronate in Japan.
Sales records
No.1 share of Sodium hyaluronate in the Japanese market.
Sales of Sodium hyaluronate to more than 30 countries worldwide.
Academic research
Kewpie has collaborated on research with many universities.
For example, our research has been about effects regarding knee joint pain and the mechanism of Hyaluronic acid when orally ingested reducing wrinkles.
We have published many studies regarding research results conducted in various journals.
High Quality and Guaranteed Safety
Made in Japan means Japanese Quality
Sodium hyaluronate for pharmaceutical grade is made at our factory near Tokyo under strict regulation and quality control.
Extremely high purity
With our manufacturing knowledge we can minimize impurities.
What are the benefits of high purity?
- ・Stable manufacturing.
It is easy to adjust the pH and viscosity levels in the manufacturing process of the drug due to the homeostasis between batches of the drug substance (always constant quality). - ・Stable quality of the drug.
- ・Maintenance of safety and effect of the final drug.
Kewpie's Sodium hyaluronate minimizes the effect of impurities on the efficacy and safety of the final drug.
Technical service
Molecular weight from 800Da to 3,500,000Da
We can cater to your specific needs by our specific technique for adjusting the molecular weight.
We not only have products of biofermentation origin, but we also have products of natural origin using our advanced extraction and refining technology.
Tailor-made Sodium Hyaluronate derivatives
By binding other functional compounds, Sodium hyaluronate can acquire a new function and are able to change the physical characteristics.
Our dedicated R&D team can provide Sodium hyaluronate derivatives according to your needs.
Product Selection
HYALURONSAN HA-AML, HYALURONSAN HA-SHL
| Product name | Average molecular weight (kDa range) |
Certificates and registrations | Intrinsic viscosity (m3/kg) |
Source |
|---|---|---|---|---|
| HYALURONSAN HA-AML |
500~1,200 | GMP CEP DMF : Japan, USA, China and Korea |
1.00~1.95 | Biofermentation |
| HYALURONSAN HA-SHL |
1,500~3,900 | GMP CEP DMF : Japan, USA and China |
2.50~5.50 | Biofermentation |
HA-SHL is suitable for crosslinking raw material.
HYALURONSAN HA-AM, HYALURONSAN HA-QSE
| Product name | Average Molecular weight (kDa range) |
Certificates and registrations | Intrinsic viscosity (m3/kg) |
Source |
|---|---|---|---|---|
| HYALURONSAN HA-AM |
600~1,200 | GMP DMF : Japan, USA, China and Korea |
1.18~1.95 | Chicken comb |
| HYALURONSAN HA-QSE |
1,900~3,900 | GMP DMF : Japan and Korea |
3.00~5.50 | Chicken comb |
HA-QSE has a much higher molecular weight than biofermentation origin Sodium hyaluronate.
About Hyaluronic acid
Structure
Hyaluronic acid is a linear polysaccharide, consisting of repetitive disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine bound by β(1→3) and β(1→4) glycosidic bonds.
Biological properties
Hyaluronic acid is prevalently distributed around cells and in the extracellular matrix of connective tissues.
It plays a lot of important roles including cell signaling, morphogenesis, wound reparation, tissue regeneration and matrix organization in our body.
Benefits of using Sodium Hyaluronate in the medical field
Sodium Hyaluronate has very unique properties such as biocompatibility, biodegradability, mucoadhesivity, hydroscopicity and viscoelasticity.
Application
- ・Knee injection
- ・Dermal filler
- ・Ophthalmic viscosurgical devices
- ・Eye drop (for dry eye)
- ・Submucosal injectable composition
- ・Resorbable adhesion barrier
- ・Wound healing agent
- ・VUR／Interstitial cystitis
We are always by your side
Science, Speed, Solution & Smile
Kewpie contributes to the health and beauty of the world
