Sodium Hyaluronate

(Hyaluronic Acid)
for pharmaceutical use

Kewpie is a Japanese manufacturer of pharmaceutical grade Sodium hyaluronate used as API and pharmaceutical excipients.
Our Sodium hyaluronate can be used for injections, eye drops and external preparations and others.
As a No.1 market share Sodium hyaluronate manufacturer in Japan, we can meet your tailor made derivatives needs.

Products Selection

Our products in powder form are available for injectable grade.


Product name Average molecular
(kDa range)
Certificates and registrations Intrinsic viscosity
Source Image
500~1,200 GMP
DMF : Japan, USA, China and
1.00~1.95 Biofermentation HYALURONSAN HA-AML
1,500~3,900 GMP
DMF : Japan, USA and China
2.50~5.50 Biofermentation HYALURONSAN HA-SHL

HA-SHL is suitable for crosslinked Hyaluronic acid


Product name Average Molecular
(kDa range)
Certificates and registrations Intrinsic viscosity
Source Image
600~1,200 GMP
DMF : Japan, USA, China and
1.18~1.95 Chicken comb HYALURONSAN HA-AM
1,900~3,900 GMP
DMF : Japan and Korea
3.00~5.50 Chicken comb HYALURONSAN HA-QSE

HA-QSE has a much higher molecular weight than biofermentation origin Sodium hyaluronate.


Knee injection
Submucosal injectable composition
Eye drop
Resorbable adhesion barrier
Ophthalmic viscosurgical devices
Wound healing agent
Dermal fillers
micro needle, drug delivery system, injectable gel, etc.

We export Sodium hyaluronate to more than 30 countries worldwide.

Contact us online

Technical Service

Molecular weight from 800Da to 3,500,000Da

We can cater to your specific needs by our specific technique for adjusting the molecular weight.
We not only have products of biofermentation origin, but we also have products of natural origin using our advanced extraction and refining technology.

Molecular weight from 800Da to 3,500,000Da

Tailor-made Sodium Hyaluronate derivatives

By binding other functional compounds, Sodium hyaluronate can acquire a new function and are able to change the physical characteristics.
Our dedicated R&D team can provide Sodium hyaluronate derivatives according to your needs.

Tailor-made Sodium Hyaluronate derivatives

Japanese manufacturing

Long history

Kewpie has been in the food industry with a history of more than 100 years.
Kewpie has continued to be a pioneer manufacturer of Sodium hyaluronate since 1983.
In 1983 we developed our first Sodium hyaluronate from Chicken comb.
Since our company also manufactures vinegar, we utilized the fermentation technology of vinegar used for our famous mayonnaise.
By using this fermentation technology we have switched our manufacturing process to biofermentation of Lactobacillus. Since 2016 we have developed and manufactured medical devices using our Sodium hyaluronate in Japan.

Academic research

Kewpie has collaborated on research with many universities.
For example, our research has been about effects regarding knee joint pain and the mechanism of reducing wrinkles through oral intake of Hyaluronic acid.
We have published many studies regarding research results conducted in various journals.
We are also looking for partners to develop new drugs using Sodium hyaluronate in the pharmaceutical use.

Customer friendly Hyaluronic acid

High Quality and Guaranteed Safety

Made in Japan means Japanese Quality

Sodium hyaluronate (Hyaluronic acid) for pharmaceutical grade is made at our factory near Tokyo under strict regulation and quality control.

Long history

Extremely high purity

With our manufacturing knowledge we can minimize impurities. What are the benefits of high purity?

  • ・Stable manufacturing.
    It is easy to adjust the pH and viscosity levels in the manufacturing process of the drug due to the homeostasis between batches of the drug substance (always constant quality).
  • ・Stable quality of the drug.
  • ・Maintenance of safety and effect of the final drug.
    Kewpie's Sodium hyaluronate (Hyaluronic acid) minimizes the effect of impurities on the efficacy and safety of the final drug.
Extremely high purity

What is Hyaluronic acid?


Hyaluronic acid is a linear polysaccharide, and the structure is consisting of repetitive disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine bound by β(1→3) and β(1→4) glycosidic bonds.



Hyaluronic acid has the physical properties of high viscosity, outstanding moisture keeping ability, lubricating effect etc., and physiological functions of wound healing, protection against infection, collagen fiber biosynthesis etc.
Hyaluronic acid has high solubility.
Hyaluronic acid is known to be degraded by heat, enzymes, etc., but can be stabilized by crosslinked structure.

Biological properties Where is Hyaluronic Acid in your body? Eye vitreous body Skin Approximately 50% of the total HA resides in the skin. Synovial joint fluid Hyaluronic Acid rich body parts

Always by your side

Customer friendly Sodium Hyaluronate

We can provide the best solution for your specific application.
We have Sodium hyaluronate with a wide range of molecular weights and are able to develop tailor made derivatives.

Timely expert technical support

We promote development for your product with our technical support by R&D experts and regulatory support.

We are always by your side


Fine Chemical Inquiries

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